Journal article
Sex-steroid hormones and risk of postmenopausal estrogen receptor-positive breast cancer: a case-cohort analysis
Frances EM Albers, Makayla WC Lou, S Ghazaleh Dashti, Christopher TV Swain, Sabina Rinaldi, Vivian Viallon, Amalia Karahalios, Kristy A Brown, Marc J Gunter, Roger L Milne, Dallas R English, Brigid M Lynch
Cancer Causes and Control | Springer | Published : 2024
Abstract
Purpose: Sex-steroid hormones are associated with postmenopausal breast cancer but potential confounding from other biological pathways is rarely considered. We estimated risk ratios for sex-steroid hormone biomarkers in relation to postmenopausal estrogen receptor (ER)-positive breast cancer, while accounting for biomarkers from insulin/insulin-like growth factor-signaling and inflammatory pathways. Methods: This analysis included 1208 women from a case–cohort study of postmenopausal breast cancer within the Melbourne Collaborative Cohort Study. Weighted Poisson regression with a robust variance estimator was used to estimate risk ratios (RRs) and 95% confidence intervals (CIs) of postmenop..
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Funding Acknowledgements
The authors thank Audrey Gicquiau for the measurement of the sex-steroid hormones and sex-hormone binding globulin, and Anne-Sophie Navionis for the measurement of the biomarkers of the insulin\insulin-like growth factor-signaling and inflammatory pathways. The authors also thank the participants of the Melbourne Collaborative Cohort Study. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database